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Clinical Trial Raises Hopes That Malaria Drug Could Be Coronavirus Cure

ArnoldZArnoldZ Member PEx Influencer ⭐⭐⭐
edited March 19 in Local and Foreign Issues

Clinical Trial Raises Hopes That Malaria Drug Could Be Coronavirus Cure


THOMAS SAMSON/AFP via Getty Images

Chuck Ross Investigative Reporter
March 18, 2020 6:29 PM ET
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  • A drug used to treat malaria is showing promise in lab and clinical studies for coronavirus, leading to reserved enthusiasm for some scientists. 
  • French researchers found that hydroxychloroquine lowered virus levels in most patients who took part in a clinical study this month.
  • President Donald Trump asked his coronavirus task force about the drug during a briefing on Wednesday. 

The results of a clinical trial in France and studies conducted in lab settings are building hope that a drug usually used to treat malaria and arthritis can treat and possibly cure coronavirus patients, though scientists say more data is needed before drawing a firm conclusion.

“It has a lot of potential, though we’re not going on a lot of data yet,” Dr. Peter Hotez, the dean for the National School of Tropical Medicine at the Baylor School of Medicine, said of early studies of hydroxycholoroquine, a malaria drug developed in the 1940s.

President Donald Trump asked the White House’s coronavirus task force about possibly using the drug, task force coordinator Dr. Deborah Birx said Wednesday.

Birx said that the drug is being studied “very carefully,” as are several other potential therapeutics.

On Tuesday, a team of French scientists released the first results of a clinical study of the use of hydroxychloroquine on 24 coronavirus patients from southeast France.

The research team, led by Didier Raoult, a renowned infectious disease expert from l’Institut Hospitalo-Universitaire in Marseille, administered the drug for 10 days along with azithromycin, a common antibiotic.

Researchers said the drugs cleared the virus in the nose and throat of most observed patients in three to six days. The study found that after six days of treatment, 70 percent of patients administered hydroxychloroquine were clear of the virus, compared to just 12.5 percent of patients who were not given drugs. 

Azithromycin boosted the effect of hydroxychloroquine, according to the study. After six days of treatment, all patients treated with the drug combination “were virologically cured,” compared to 57.1 percent of patients treated with hydroxycholorquine by itself.

“We therefore recommend that COVID-19 patients be treated with hydroxychloroquine and azithromycin to cure their infection and to limit the transmission of the virus to other people in order to curb the spread of COVID-19 in the world,” wrote researchers, who acknowledged the small sample size of the study.

Vice President Mike Pence and the White House coronavirus task force (Drew Angerer/Getty Images)

Lab studies have shown that hydroxychloroquine, which was developed in the 1940s, inhibited coronavirus. A study published in Cell Discovery on Wednesday by three Chinese scientists found that hydroxychloroquine inhibited coronavirus in vitro, or in a lab culture.

Hotez, the infectious disease expert, told The Daily Caller News Foundation he was “enthusiastic” about early results of studies involving hydroxychloroquine, though he said more data is needed to determine if the drug can effectively treat coronavirus.

“We urgently need to accelerate new antimicrobial therapies. If hydroxychloroquine could be approved in therapy it would be a game-changer,” Hotez said.

“The important next step is to show that it has an impact on reducing severity of symptoms in clinical disease.”

Hotez said that an ideal study would be conducted in areas with high rates of transmission, such as the Lombardy region in Italy.

More clinical trials are underway. A researcher at Asan Medical Center, a top research hospital in South Korea, is conducting a clinical trial of 150 patients with mild cases of coronavirus. The lead researcher, Sung-Han Kim, estimates that the trial will be completed in May.

According to NBC News, French drug maker Sanofi is working with health authorities to study whether hydroxychloroquine can help with coronavirus. The company is encouraged by preliminary findings, according to NBC News, but still does not have enough data to determine its efficacy.

Health officials in Belgium and South Korea have recommended the use of hydroxychloroquine patients displaying either severe or mild symptoms from COVID-19, the disease caused by coronavirus.

The United Kingdom appears to have some hope for the drug. On Sunday, government officials there banned the export and hoarding of hydroxychloroquine and two other drugs that could be useful as therapeutics, according to Pharmaceutical Technology.


Is this the proverbial lght at the end of the tunnel?



  • joerizjoeriz Member PEx Influencer ⭐⭐⭐
    edited March 19
    Malaria is a common disease in the Philippines. There must be a lot of this malaria drug in Philippines' pharmacies and hospitals.
    Duque, what are you waiting for? Initiate clinical tests! Better yet, start treating high risks infected patients, already!
  • ArnoldZArnoldZ Member PEx Influencer ⭐⭐⭐
    edited March 19

    Bayer Is Donating Its Malaria Drug That Could Help Coronavirus Patients In The U.S.

    Early studies have shown the decades-old drug holds promise for treating the disease caused by the novel coronavirus.

    Mark Prvulovic
    Mar 18, 2020 at 9:57PM

    With no vaccines or treatments for COVID-19 on the market, many healthcare companies are evaluating existing drug treatments to see if they could be effective in COVID-19 patients. Bayer (OTC:BAYRY) is preparing to donate a large supply of an older malaria drug to the U.S. government, according to Axios.

    While there's still plenty of testing that would need to be done, Bayer's anti-malarial treatment, chloroquine, is relatively inexpensive while possibly being just as effective as other antiviral COVID-19 treatments being developed right now. The most prominent of which is remdesivir, Gilead Sciences' (NASDAQ:GILD) former Ebola drug that's now in late-stage testing as a COVID-19 treatment.

    A medical professional in a facemask holding an intravenous treatment

    Image source: Getty Images.

    One study published in Nature found that remdesivir and chloroquine are both effective in suppressing COVID-19 in vitro (in test tubes). While it's just one study, these initial results are promising enough for healthcare authorities to further investigate chloroquine as a potential treatment in the future.

    Remdesivir had a similar start, with clinical testing for the drug having begun shortly after it was used on a compassionate use basis for a COVID-19 patient showing severe symptoms.


    Bayer had to donate the medication to the entire world! First and foremost, to Italy.
    The Defense Production Act invoked by Pres. Trump must be used for massive manufacture of the malarial drug.
  • TrollmasterTrollmaster PEx Rookie ⭐
    ito na sana!
  • joerizjoeriz Member PEx Influencer ⭐⭐⭐
    Department of Health should immediately initiate administering the malaria drug to COVID-19 patients
  • ArnoldZArnoldZ Member PEx Influencer ⭐⭐⭐
    edited March 19

    Here’s why Trump and Elon Musk see potential in a drug called chloroquine to treat coronavirus

    Published Thu, Mar 19 20203:27 PM EDTUpdated 9 min ago
    Key Points
    • What is chloroquine and why is it considered a promising potential treatment for COVID-19?
    • Elon Musk and President Trump have both touted the drug on social media. 
    • The early data is promising, scientists and biotech experts say. But there are still many unknowns. 
    AP Elon Musk and Donald Trump 170203
    President Donald Trump talks with Tesla and SpaceX CEO Elon Musk at Trump Tower last February.
    Evan Vucci | AP

    When Dr. Mike Pellini, a physician and biotech investor, read the news about the spread of a virus that caused pneumonia-like symptoms, he decided to keep on hand a supply of an anti-malarial drug called chloroquine. 

    Pellini, who tweeted about the decision to his followers in early February, was early to this thinking. A month later, Tesla CEO Elon Musk sparked massive interest in the drug after tweeting that chloroquine was “maybe worth considering” as a potential treatment for the COVID-19 coronavirus.


    On Thursday, the White House took notice.

    President Donald Trump said he had directed the Food and Drug Administration to investigate whether chloroquine, which is available by prescription only, should be given to patients with the virus. Bayer, the international drugmaker, then noted in a press release that it would donate 3 million tablets of the drug Resochin, or chloroquine phosphate, to U.S. patients. Trump also pointed to another existing drug, Remdesivir, an anti-viral developed by the drugmaker Gilead, which is already being used in China to treat COVID-19. 

    Neither drug is currently approved by the FDA to treat the coronavirus. So it is important “not to provide false hope,” FDA Commissioner Stephen Hahn said at the White House’s daily press briefing. But Trump has “asked us to be aggressive” and “break through exciting, life-saving treatment, and we’re doing that at the FDA,” he added. 

    Early promising data 

    So what is chloroquine, and why is it considered so promising by the scientific community?

    The drug has been around since the 1940s and is known for being generally safe and well-tolerated in mild to moderate doses, although it can be toxic in high doses. It has been used to treat malaria, in addition to some autoimmune disorders. It is available as a generic, which means it could be a scalable and potentially affordable treatment.

    “Nothing is definitive yet, but chloroquine is a drug used for more than 70 years with minimal side effects at a modest dosage,” said Dr. Pellini. ........
    Very interesting!
    For more,l follow this link -

  • topnotch97topnotch97 Marley Brinx says hi PEx Influencer ⭐⭐⭐
    there are mixed reports that the malaria drug has been approved by the FDA.
    other news contradict that the FDA hasn't done any approval for use.
  • joerizjoeriz Member PEx Influencer ⭐⭐⭐
    there are mixed reports that the malaria drug has been approved by the FDA.
    other news contradict that the FDA hasn't done any approval for use.

    One way of determining which to believe is by knowing the source.
  • hsusonhsuson Member PEx Influencer ⭐⭐⭐
    FDA takes many months of testing before approval of the malaria drug for coronavirus use.

    Fake news yung approval
  • Plantation BoyPlantation Boy Member PEx Influencer ⭐⭐⭐
    Shouldn't Philippine hospitals stockpile hydroxychlotoquinine, too?


    Hospitals Stockpile Drug Trump Says Could Treat Covid-19

    March 20, 2020, 2:17 PM PDT Updated on March 20, 2020, 6:46 PM PDT
    • Health systems more than doubled orders of hydroxychloroquine
    • Panic buying spurred by preliminary Covid-19 drug research

    Hospitals have been rushing to stockpile a decades-old antimalarial drug touted by President Donald Trump and others as a treatment for the new coronavirus.

    Hydroxychloroquine is being snapped up by medical systems at more than twice the typical pace as U.S. hospitals seek to build large inventories in anticipation of the medication’s potential use in patients with Covid-19, the respiratory illness caused by the coronavirus.

    From March 1 through March 17, U.S. hospitals bought an average of 16,110 units of hydroxychloroquine, compared with an average 8,800 units a month from January 2019 through February 2020, according to Premier Inc., which helps 4,000 member hospitals buy and manage their supplies.

    Hydroxychloroquine and its more-toxic cousin chloroquine, which are also commonly used to treat rheumatoid arthritis and lupus, haven’t been approved by the U.S. Food and Drug Administration for Covid-19. While Trump has touted some reports from doctors outside the U.S. suggesting hydroxychloroquine could be a promising treatment, there have been no large-scale clinical trials to support those claim

  • hsusonhsuson Member PEx Influencer ⭐⭐⭐
    Anecdotal lang.

    No clinical trials state that those drugs work on Coronavirus.
  • Plantation BoyPlantation Boy Member PEx Influencer ⭐⭐⭐
    hsuson said:
    Anecdotal lang.

    No clinical trials state that those drugs work on Coronavirus.

    The thread is about clinical trial by French researchers.

  • Plantation BoyPlantation Boy Member PEx Influencer ⭐⭐⭐

    US prescriptions are spiking as the UK guards its supply

    While peer-reviewed results are the standard in medicine, the lack of that data hasn't prevented the world from acting. China has found that chloroquine is effective against COVID-19, the state-owned Xinhua news agency reported on February 17. Countries including China, South Korea, and Belgium have added chloroquine to their treatment guidelines. US physicians don't appear to be waiting for data either. Prescriptions for chloroquine have surged, according to recent tracking data from IQVIA cited by Raymond James. For the weeks of February 21, February 28, and March 6, weekly prescriptions grew from 531 to 957 to 1,290. Doctors in the US have broad authority to prescribe approved medications for so-called off-label uses, or conditions that the drug isn't approved to treat. In the past month, the UK has added both chloroquine and hydroxychloroquine to a list of drugs that drug wholesalers cannot export because UK patients need them and exporting them may lead to a shortage in the UK.

    Early reports of success 'should be taken seriously'

    Andrea Savarino is an Italian scientist who has worked at the Italian National Institute of Health, the country's top medical research body, since 2006. He has been studying chloroquine and its potential uses for even longer than that, starting as a virologist in 1994. During the 2003 outbreak of SARS — also a coronavirus — Savarino showed in laboratory research that chloroquine may be a useful weapon against it. But by the time his research was published in The Lancet in November 2003, the outbreak had dissipated and there were no human cases available to test. "There has been a number of press releases, unfortunately not yet papers, but even the local experiments are things that should be taken seriously," Savarino told Business Insider. "Chloroquine plus the HIV inhibitors has produced interesting results, at least curative results, both in China and Australia." In Australia, researchers at the University of Queensland have said a combination of chloroquine and Kaletra led to the recovery of some of the first COVID-19 patients in Australia. "It's a potentially effective treatment," David Paterson, the director of the university's Centre for Clinical Research, told the Australian news site News.com.au. Savarino said he had heard anecdotal accounts from other countries as well, including Japan, India, and Thailand. "Given these promising results, I am of course optimistic, but I cannot give percentages of success as of now," Savarino said. He emphasized the need to collect more data before reaching conclusions. Savarino said he was developing an online platform to collect hydroxychloroquine data on COVID-19 patients across Italy and eventually other countries. He said he hoped to get the site going in the next few days and would make the data widely available as soon as possible. Ultimately, Savarino thinks a combination of two or three drugs will be found to be the most effective treatment for COVID-19, like how therapies using multiple drugs have become the standard for treating HIV, he said.
  • hsusonhsuson Member PEx Influencer ⭐⭐⭐
    edited March 21

    Reporters asked  Dr. Fauci, in front of Trump — if a malaria drug called hydroxychloroquine could be used to prevent COVID-19, the disease caused by the virus

    Fauci took the reporter's question and got right to the point.

    “No,” he said. “The answer ... is NO.

    “The information that you're referring to specifically is ANECDOTAL,” Fauci added firmly. “It was not done in a controlled clinical trial, so you really can't make any definitive statement about it.”

  • Plantation BoyPlantation Boy Member PEx Influencer ⭐⭐⭐
    Fauci of NIH had partnered with Moderna to develop a COVID-19 vaccine!  Millions of dollars in that!
    His partnership will be in trouble if he even hints hydroxychloroquinine has the possibility of curing COVID-19 patients!

  • hsusonhsuson Member PEx Influencer ⭐⭐⭐
    This cure is based on a few  subjects, which does not give a great deal of confidence,” said Hank Greely, a bioethicist at Stanford University, said of hydroxychloroquine. “This study is promising, provocative and worth following-up on, but it is nothing more than that.”
  • topnotch97topnotch97 Marley Brinx says hi PEx Influencer ⭐⭐⭐
    kasi nga baka gamitin yan na walang pakundangan. ie China.

  • Plantation BoyPlantation Boy Member PEx Influencer ⭐⭐⭐
    edited March 23
    Wife: "Honey, you are dying. You can hardly breathe. Do you want to try the anti-malarial drug that shows promise of curing your condition?'

    Husband: "NO! That's just ANECDOTAL!"

    And those were his last words.

  • hsusonhsuson Member PEx Influencer ⭐⭐⭐
    edited March 23
    Wife: "Honey, you are dying. You can hardly breathe. Do you want to try the anti-malarial drug that shows promise of curing your condition?'

    Husband: "NO! That's just ANECDOTAL!"

    And those were his last words.

    Gov't officials: "Emperor Chin, you are dying. You can hardly breathe. Do you want to try the liquid mercury that shows promise of curing your condition?' 

    Chin, Emperor of China: "YES!"

    And those were his last words.

    Hydroxychloroquine is an anti-protozoa. Not an anti-virus medicine.

    You dont know if those french doctors injected this drug into the younger stronger patients.  Or the few good results were caused by the Placebo effect. Or by pure chance.

    That is why a careful, randomized clinical trial is needed test the TRUE efficacy of any drug. Hindi pwede yung "sabi-sabi" lang.

    Precisely why the medicines we have now are so effective.

  • Plantation BoyPlantation Boy Member PEx Influencer ⭐⭐⭐
    edited March 24
    Some medicines are so effective.....in killing, too!

    10 Most Dangerous Drugs Prescribed By Doctors
    February 18, 2019|

    Jonathan Rosenfeld Share this PostTweet this PostShare on FacebookShare on LinkedIn 10 Most Dangerous Prescription Drugs Research from Johns Hopkins suggests that medical errors constitute the third most common cause of death in the United States. Prescription errors account for far too many of these deaths, with a few drugs, in particular, responsible for a shocking level of suffering. Several of the most dangerous prescription drugs are highlighted below:

    1. Fentanyl If used properly, opioids can play an important role in pain management. Unfortunately, these drugs carry significant risks, including, most notably, the potential for abuse. Fentanyl, in particular, has seen skyrocketing abuse in recent years. In 2017, the Centers for Disease Control estimated that 29,406 Americans died due to overdoses involving the category of synthetic opioids dominated by fentanyl. While many of these deaths were related to illicitly obtained substances, many others involved prescribed medications.

    2. Oxycodone Oxycodone (which is featured in such brand-name drugs as Oxycontin and Percocet) can, like fentanyl, provide pain relief to those who need it most. It can also easily be abused. The drug is particularly dangerous if mixed with alcohol or other substances. A recent study indicates that just one oxycodone tablet can significantly increase the risk of respiratory depression if taken with alcohol.

    3. Methadone While some medical professionals peg methadone as a safer alternative to opioid painkillers, it carries considerable risks of its own. Experts at MDedge point to methadone’s variable dose-response relationship, which, over time, can prompt the same respiratory depression that those who take oxycodone may face. Because methadone takes time to kick in, the risk of accidental overdose may actually be greater.

    4. Warfarin While the anticoagulant warfarin has been successfully used to treat patients for several decades, a recent analysis conducted by ProPublica suggests that the drug is riskier than many people suspect. Nursing homes, in particular, are plagued by warfarin issues, with experts estimating that thousands of related hospitalizations and deaths go unreported every year.

    5. Statins Experts remain at odds regarding statins — a common type of cholesterol-lowering drug intended to reduce the risk of heart attack and stroke. Authors of a study published in the Journal of the American Medical Association worry that the medical community has not yet perfected guidelines for determining who should and shouldn’t be prescribed statins.

    6. Alprazolam Better known as Xanax, alprazolam can, like many tranquilizers, be easily abused. It’s also dangerous in that it can prompt a variety of negative effects with long-term use, including mood swings and fatigue.

    7. Anabolic Androgenic Steroids Anabolic steroids have hit headlines for years due to the prevalence of their use (and abuse) in professional athletics. In the healthcare industry, they’re commonly prescribed for ailments that prompt muscle loss. While they do not have discernable short-term effects on the brain, they can have a long-term negative impact on mental health, with abusers often demonstrating paranoia and aggression. Long-term use could also lead to kidney failure, liver damage, high blood pressure, and an increased risk of blood clots.

    8. Methotrexate Commonly used to treat rheumatoid arthritis, methotrexate has caused alarm in the medical community due to its ties to melanoma and other malignancies. If taken too frequently, methotrexate can suppress bone marrow and increase the body’s susceptibility to infection. Taken just three days in a row, the drug can dramatically increase the risk of sepsis.

    9. Dextroamphetamine Sometimes abused by those not diagnosed with attention-deficit hyperactivity disorder, dextroamphetamine (better known by the brand name Adderall) can prompt high blood pressure, sleep disturbances, or irregular heartbeat with prolonged use. The FDA also notes a slight risk of mood swings or even psychosis.

    10. Antibiotics Antibiotics can offer quick relief for a variety of ailments, but their use isn’t always necessary — and sometimes, it can be dangerous. Experts at the CDC believe that between one-third and one-half of antibiotic use is either unnecessary or inappropriate. This can lead to adverse side effects and may hasten the growing threat of antibiotic resistance. If you believe improper prescriptions have caused you undue suffering, it’s time to take action.

  • hsusonhsuson Member PEx Influencer ⭐⭐⭐
    ^No matter how much you wish, the FDA will not approve hydroxychloroquine as a treatment for Coronavirus without extensive   clinical trials.

    Kahit umiyak at lumuhod si Trump, it won't happen.

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