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Information Drive -- All about Glutathione and its link to many diseases.

What Everyone Needs to Know About Glutathione

Back in 1747, James Lind's discovery that Vitamin 'C' could cure scurvy was a major medical breakthrough, that saved countless lives.

Since then, Vitamin C has been found to be beneficial for many other things as well. However, it wasn't until 1954 that scientists began to understand exactly why it's so powerful. During that year, a researcher named Dr. Denham Harman formulated the free radical theory of aging. This theory suggested that aging is actually caused by free radicals, which attack and damage the cells of the body. Dr. Harman further theorized that this process could be slowed by antioxidants, nutrients with the power to neutralize free radicals and heal the cellular damage caused by them.

Other scientists at first scoffed at Dr. Harman's idea; however, it has since been proven by numerous studies. It is now known that Vitamin C is an antioxidant and that is why it has so many benefits.

In recent decades, however, researchers have discovered an antioxidant that is even more powerful. It is known as Glutathione, and it is present in every cell of the body.

WHAT IS GLUTATHIONE?

Glutathione is produced naturally in the liver. It is made up of three amino acids, and it is vital for cellular metabolism. It protects against oxidative stress caused by free radicals, is required for the immune system to function properly, and is a potent detoxifier.

The importance of glutathione has been validated by over 92,000 scientific articles, more than twice the amount that has ever been published about vitamin C. In fact, nutrition experts believe that it is just as necessary for our health as oxygen, food and water.

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WHY DO WE NEED GLUTATHIONE?

Glutathione helps other antioxidants and nutrients do their jobs properly. Without it, no amount of supplementation or healthy eating will do us any good. In addition, since our immune system depends on this substance, a lack of it causes us to get sick more often. It also protects our mitochondria, which provide energy to our cells. Our mitochondria are very vulnerable to the effects of free radicals, so if glutathione weren't present they would deteriorate very quickly and our cells would die.

Furthermore, this antioxidant helps our body get rid of toxins. This is important, because most of us are exposed to dangerous chemicals on a daily basis. In fact, a study by Cornell University found that over 60% of the world's population is harmed by air pollution, and the Institute of Occupational Safety and Health recently found that almost 900 of the chemicals used in cosmetics and skincare products are toxic.

Although glutathione is produced naturally in the body, its levels begin to decline at around twenty years of age. From that point, they decrease by 8% to 12% every decade.

By the time a person is 50, these levels are only at 60% to 70% of what they were in their teens.

The level of glutathione in our body is also lowered by sickness, toxins and other things that cause physical or emotional stress. Because it is nearly impossible to avoid these things with our modern lifestyle, most people do not have enough glutathione in their bodies.

Glutathione has been widely studied with over 99,000 published peer-reviewed scientific papers on this topic. In one review, almost 80% of people with chronic ailments were found to be deficient in glutathione. In fact, low levels of glutathione are involved in all disease states. The following symptoms, diseases and illnesses have been linked to low glutathione levels. (To find the scientific papers that have been published on each of these topics in relation to glutathione, visit www.pubmed.gov and type in “glutathione” and the symptom/disease/illness/syndrome of interest).

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More...

Glutathione is a small protein produced naturally in our cells when certain required elements are present. It functions both as an antioxidant and a detoxifier and is a major defense system against illness and aging. Our glutathione level indicates our state of health and can predict longevity. Although there are more than 99,000 published papers on the beneficial effects of glutathione replacement, it is still largely ignored by mainstream medicine.

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Increasing intracellular glutathione levels has been shown to:

dramatically increase energy levels;
strengthen the immune system;
aids cell detoxification;
chelate heavy metals like mercury (i.e., bind to heavy metals, so that they can be removed from the body);
fights off the damage of free radicals on the cells;
slow down the aging process;
reduce inflammation or swelling;
improve athletic performance and recovery;
detoxify and improve liver function;
increase stamina and endurance;
improve memory and other mental functions;
improve vision;
improve heart and lung function;
aids muscle and joint recovery;
mood improvement;
improves quality of sleep;
improves the health of skin and decreases wrinkles;
eases anxiety; and
protects from degenerative diseases and reduces the chances of developing cancer

“Glutathione levels go down in every age group except one and that one are the people who reach a hundred years of age. Those people, interestingly, have glutathione levels that approximate those of a normal 30 to 40 year old.”
- Dr. Robert Keller

Glutathione levels decrease as a result of:

aging (glutathione levels decrease by 10-15% every decade);
stress;
inflammation;
sun exposure;
athletic activities;
sleep deprivation; and
environmental toxins.

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How do you increase glutathione levels?

Increasing intracellular glutathione levels is typically a complicated process. Glutathione can be taken intravenously, transdermally or through a nebulizer. Note that supplementing directly with oral glutathione is generally not effective because studies have found that glutathione does not survive the digestive process. Furthermore, supplementing with oral glutathione can result in a yeast outbreak and gut imbalance. Injections are only minimally useful, since glutathione cannot enter into the cells themselves. It must be manufactured inside the cells (when the necessary components are available.) As Dr. Kartzinel explains, methyl B12 injections and supplementing with trimethylglycine (TMG) or dimethylglycine (DMG), folic acid and N-acetyl-cysteine can increase glutathione levels.

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Check this long list of diseases associated with low glutathione levels and its scientific papers published in pubmed.

http://glutathioneforhealth.wordpress.com/health-concerns/

name a particular disease and its highly likely due to glutathione deficiency. here's what experts have to say about glutathione

and this

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Comments

  • best explaination why low glutathione levels are directly linked to diseases and illnesses :)
  • Glutathione Deficiency

    What causes Glutathione deficiency?
    Your Glutathione Levels are Falling whether you like it or not. Glutathione levels diminish as we age. Your body's natural glutathione production begins to decline by 10% to 15% per decade starting at the age of 20. Glutathione deficiency is alarming because all other antioxidants rely on the presence of glutathione to function and do their job properly. This is the main reason that as we age (hence glutathione levels become lower) we become prone to illnesses.

    "Clinical evidence links low glutathione levels to the most common illnesses of our time as well as newly emerging diseases." Glutathione: Essential Health AID - Antioxidant, Immune Booster... Dr. Jimmy Gutman, MD, FACEP.

    Diseases Associated with Decreased (Low) Levels of Glutathione

    GENERAL
    Obesity, Immune Signaling, Endothelial dysfunction, Alcoholism,
    Inflammation. Heavy metal poisoning.

    CARDIOVASCULAR
    Angina and spastic angina, Unstable angina, Heart attacks, Positive
    stress tests, Reperfusion after cardiac bypass surgery, hypertension

    PULMONARY
    Emphysema (COPD), Pulmonary fibrosis (IPF), Asthma, Muscle wasting
    in COPD, Chronic bronchitis, Tobacco abuse

    NEURO/PSYCH
    Migraine headaches, Alzheimer's, Parkinson's, Multi infarct dementia,Autism, ADHD (Attention Deficit Hyperactivity Disorder), Bipolar disease, Schizophrenia, Lou Gehrig's disease, Huntington's chorea, Multiple Sclerosis, Depression

    INFECTIOUS DISEASES/IMMUNOLOGY
    Hepatatis A, B, and C, Herpes Simplex, Herpes Zoster/Shingles, Influenza and Bird Flu, HIV, MRSA, Common viral infections (upper respiratory, gastroenteritis), others.

    RHEUMATOLOGY
    Systemic Lupus Erythematosus (SLE), Rheumatoid Arthritis (RA), Multiple Sclerosis, Systemic Sclerosis (Scleroderma) Syndrome, Behcet's Syndrome, ME/CFS, Fibromyalgia, others.

    DERMATOLOGY
    Wrinkles (sagging), Acne, Psoriasis, Atopic Dermatitis, Eczema, Others.

    ONCOLOGY - Every Cancer studied including Brain cancer, Head and Neck cancer, Thyroid/Lung/Esophagus/Stomach cancer, Intestine cancer, Liver cancer, Pancreas/Kidney/Uterine/Ovarian Cancer, Prostate Cancer, Leukemia (acute and chronic), Lymphoma, Multiple myeloma, others.

    OB/GYN
    Infertility, Spontaneous abortions, Pre Menstrual Syndrome

    OPTHAMOLOGY
    Cataracts, Macular Degeneration

    Correction of Glutathione Deficiency
    Studies have demonstrated that oral glutathione is not well absorbed by many of the mammal's cells and does not replenish losses inside cells where it is most needed.
  • Diabetes and Glutathione

    What is Diabetes?
    A disorder of glucose or blood sugar metabolism. The body is not capable of breaking down glucose in the blood stream.

    Major Types of Diabetes
    Type 1 diabetes - the body is unable to produce insulin that is needed to break down blood glucose so the body may use it.
    Type 2 diabetes - the common type of diabetes where the body has the ability to produce the needed insulin, but it cannot be recognized by the cells. The major cause of type 2 diabetes is obesity.

    Diabetes Symptoms
    Studies indicate that early detection of diabetes symptoms and treatment may lower the chance of having diabetes complication. Diabetes often goes undiagnosed because many of its symptoms are harmless.

    Type 1 Diabetes Symptoms
    Frequent urination
    Unusual thirst
    Extreme hunger
    Unusual weight loss
    Extreme fatigue and Irritability

    Type 2 Diabetes Symptoms
    Any of the type 1 symptoms
    Frequent infections
    Blurred vision
    Cuts/bruises that are slow to heal
    Tingling/numbness in the hands/feet
    Recurring skin, gum, or bladder infections
    Note: some people with type 2 diabetes have no symptoms

    How can we control or treat Diabetes?
    Regular exercise and Healthy diet is essential, foods high in fiber, nuts, onions and garlic are a good food choice to control blood glucose at a safe level. Apart from diet and exercise, antioxidant supplement is also needed. Exogenous Antioxidants that we get from food we eat is not enough if you have diabetes because your body is compromised and may not have the ability to use it efficiently. We need the help of Endogenous antioxidants to overcome diabetes naturally.

    Based on research, diabetics have high level of oxidative stress and low levels of natural glutathione gsh. Oxidative stress is produced under diabetic conditions and possibly causes various forms of tissue damage in patients with diabetes. Complications will arise under these circumstances; the most common is heart disease, for people suffering from diabetes.

    It is recommended for diabetics to increase their natural glutathione level. Glutathione, being the most prevalent endogenous antioxidant, can neutralize oxidative stress or free radicals. It also has the ability to repair damaged cells, which will result to healthy tissues and healthy organs.

    How to increase Glutathione Level?
    You can use glutathione accelerator or supplements that can give your body the nutrients needed so that your cells can manufacture it at the cellular level.

    How to Regulate or Control Blood Sugar Level
    Antidiabetics maintenance medicine for those with diabetes might be needed, but utmost care should be made. It can deplete you of essential nutrients needed by your body.
  • Glutathione and Migraine

    What are Migraines?

    Migraine is a chronic disorder characterised by recurrent severe headaches that can last up to 72 hours. The headache is often unilateral (one sided). Associated symptoms may include nausea, increased sensitivity to light and sound, and aura. Migraines are more common in women, and may possibly be related to fluctuating hormone levels. Certain triggers may also be a cause for migraine such as stress, exercise, hunger, toxins, food additives (eg MSG), alcohol, caffeine, electromagnetic radiation, the menstrual cycle and fatigue.

    The Role of Glutathione
    Glutathione is the brain's most important antioxidant and free radical scavenger. Glutathione plays a vital role in mopping up harmful toxins, so if glutathione get depleted these toxins can accumulate and cause cell damage. Glutathione is able to chelate and remove mercury from the body via the liver. Glutathione also plays a vital role in the production of melatonin, an endogenous antioxidant that is involved in regulating our circadian rhythms.

    How is Migraine Treated?
    Migraine sufferers typically take pain relieving medications (such as aspirin, ibuprofen, paracetamol or acetaminophen), however these medicines have the unfortunate side effect of further depleting glutathione stores in the body.

    The Natural Approach
    Increase your body's natural production of glutathione by taking glutathione accelerator. Taking whole glutathione supplements are deemed useless since it will be broken down as it passess the gastrointestinal tract. Injectables (IV) are also less effective because the glutathione molecule is too big to pass the cell membrane.
  • Asthma and the importance of glutathione
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    Asthma is a common chronic inflammatory disease of the airways characterised by wheezing, coughing, chest tightness, and shortness of breath.

    Chronic oxidative stress and the depletion of the endogenous antioxidant glutathione play a key role in the development of the chronic obstructive pulmonary disease (COPD) and asthma.

    Oxidative stress and depleted gluathione levels can trigger an attack
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    High oxidative stress coupled with depleted glutathione levels makes this chronic condtion worse. It also explains why some of the typical triggers make asthma worse. Exercise creates significant oxidative stress. In asthmatics whose glutathione levels are already low, this additional oxidative event can be enough to trigger an attack. A similar phenomenon is seen in people with COPD.

    Supplementing Glutathione levels is of benefit in Asthma
    Increase your body's natural production of glutathione by taking glutathione accelerator. Taking whole glutathione supplements are deemed useless since it will be broken down as it passess the gastrointestinal tract. Injectables (IV) are also less effective because the glutathione molecule is too big to pass the cell membrane.
  • Glutathione and Cardiovascular Disease

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    Cardiovascular disease remains the biggest cause of deaths worldwide. The risk factors for cardiovascular disease have traditionally been considered age, high blood pressure, high cholesterol, smoking, family history, poor diet and a lack of exercise. More recently doctors are realising the importance of underlying inflammation and are using blood levels of inflammatory markers (eg C reactive protein) to predict coronary risk.

    What your doctor may not tell you

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    In his book What your doctor may not tell you about heart disease (see extract to the right), Dr Mark Houston explains that low glutathione levels are a strong predictor of a possible heart attack. A lack of gluathione has been associated with increased free radical and oxidative damage.

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    Oxidative stress is now recognised as a key event in the development of atherosclerosis. An initial oxidative injury to a blood vessel triggers the artery to form a cholesterol cap over the area of injury. Over time, this can build up into a fatty plaque which can grow large enough to stop the flow of blood. Thrombus (blood clot) can form over the plaque and break off, blocking supply to blood to vital organs such as the brain (resulting in a stroke) or heart (resulting in a heart attack). Since oxidative injury is the first step in cardiovascular disease, it makes sense that sufficient antioxidant defence is required to stop the damage.

    Increasing glutathione levels will:
    Lower blood pressure
    Reduce the risk of heart attack
    Improve immune function
    Decrease inflammation
    Improve vascular health
    Protect cells from the damaging effects of free radicals
    Slow the oxidation of fats
    Assist with the uptake of other antioxidants
  • if you are still in doubt about these claims, you can do more research... but this genius already did :)

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    Dr. Robert H. Keller, MD, MS, FACP, was a triple board certified physician and research scientist. A brilliant scholar, Dr. Keller had a distinguished academic career and highly acclaimed researcher of Gutathione.

    Dr. Rob Keller had served on the scientific review panels for the National Institutes of Health and the United States Department of Veterans Affairs. Dr. Keller was a faculty member of the Mayo Graduate School of Medicine, the University of Wisconsin and the Medical College of Wisconsin (Marquette Univ.).

    Notable Honors & Awards:

    Named one of the world’s 2,000 Outstanding Scientists of the 21st Century
    Elected to The Board of Governors of the American Academy of HIV Medicine
    Recognized as one of America’s “Top Physicians in 2003, 2004, 2005, 2006, and 2007 in the fields of Internal Medicine, Immunology and Hematology
    Humanitarian of the Year award by the National Hemophilia Foundation in 1999
    Featured in the “Guide to America’s Top Physicians”


    Dr. Robert H. Keller published more than 100 original articles in various scientific and medical journals and was awarded several patents. He wrote a book, GLUTATHIONE Your Best Defense Against Aging, Cellular Damage and Disease. This in-depth monograph explains why Glutathione is the most powerful and life-sustaining antioxidant in the human body.

    Dr. Keller passed away in 2009; He is remembered as an exceptional scientist, compassionate physician and an accomplished educator. Thousands continue to attribute their improved health and vitality to the discoveries and patented formulations of Rob Keller MD. This is the Curriculum Vitae of Dr. Robert Keller, as of the date of his untimely passing.

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    and don't miss this lecture he had years ago after researching glutathione from pubmed
  • The Roles of Glutathione

    Is Your Body’s Master Antioxidant
    It is considered the master antioxidant due to its unique multifunctional characteristics as well as its unprecedented ability to neutralize many types of free radicals that assault the cell. It is the only antioxidant that can recycle itself again and again to continually fight free radicals.

    Is The Primary Detoxifier of the Cell
    Today we are confronted by over 80,000 chemicals in the air we breathe, the food and water we ingest, and the materials we touch and handle. Many of these toxic chemicals enter our cells and must be eliminated to protect the cell and maintain optimum function. Glutathione is the cell's first line of defense against chemicals and toxins and the primary detoxifier that can eliminate many of these toxins when it is present in optimal amounts.

    Is A Powerful Chelator of Heavy Metals
    Heavy metals enter our cells in the same manner as chemical toxins. Fortunately, they can be removed from the cell by a process of chelation, and glutathione is one of the cell's most powerful chelating agents.

    Is The Protector of the Immune Cell
    Our immune cells are designed to protect us. but what protects the immune cell? Glutathione is the protector of the immune cell and allows newly formed immune cells to proliferate to attack germs and viruses.

    Is The Protector of Mitochondrial DNA
    The breakdown of the mitochondrial DNA accelerates aging and increases cell death. Glutathione is the protector of the Mitochondrial DNA, and the lower the glutathione level, the more vulnerable this DNA becomes to breakage.

    Is The Protector of the Nucleus of the Cell
    The nucleus of the cell regulates all cell activity and protecting it is critical to the health of the cell and its optimal function. When present in sufficient amounts, glutathione gives the nucleus the protection it needs.

    Reduces Oxidative Stress
    Oxidative Stress is the most aggressive destructive force that assaults the cell. Cells manufacture a number of antioxidants to counter oxidative stress. Glutathione plays a primary role in neutralizing many different types of free radicals and supporting our antioxidant defense system.

    Reduces Intracellular Inflammation
    Inflammation is the mortal enemy to the tissues, organs and various systems of the body. All inflammation begins at the cellular level, and low glutathione levels are associated with inflammation.

    Is The Re-Utilizing Agent of Ingested Antioxidants
    Antioxidants that are ingested (not manufactured by the body such as vitamin C and E), once spent becomes a weak free-radical and cannot be re-utilized by the cell unless they are first converted into a usable state (antioxidant state). Glutathione is the agent that converts those 'used' antioxidants (weak free-radical) into a state that can be utilized by the cell.

    Is The Reducing Agent for Hemoglobin, Allowing it to Transport Oxygen to Every Cell
    The purpose of hemoglobin is to carry oxygen to all living cells. However, when it is oxidized it cannot carry an oxygen molecule and must first be reduced to an acceptable state. Glutathione protects hemoglobin from oxidizing agents and can also reduce the oxidized form to make this possible.
  • Glutathione and Cancer

    First of all, what is Cancer?

    Cancer is the SYMPTOM of DNA mutation, abnormal growth of damaged cells. DNA controls cell growth, development and replication. When the DNA gets damaged, it can replicate an altered (damaged) cell - and when this altered cell replicates itself.... This can become CANCER.

    Please Take Note: Symptoms alert YOU that something isn't right in your Body but they are not the Cause of Illness or Disease.

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    Did You Know That Cancer is associated with Low Levels of Glutathione GSH?

    Read More : Glutathione Deficiency

    "The Precursor To Fight Cancer Lies In Prevention"

    So How can we prevent Cancer?
    Since healthy DNA is needed to prevent replication of mutated cells, we need to protect it from free radicals by the aid of Antioxidants.

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    Antioxidants have "extra" electrons that they can give to free radicals. By doing that, it eliminates its harmful effect. Antioxidants are the body's defense against destructive free radicals which causes aging, sickness and disease.

    What Type of Antioxidant Do We Need???

    Exogenous Antioxidant
    If we will take Exogenous Antioxidant like the famous Vitamin C and Vitamin E, we are protecting our cells from being damaged, but it cannot repair or restore damaged cells. It only shields our body from incoming free radicals. In other words, exogenous antioxidant has no ability to neutralize or stop mutated cells to grow erratically. We should also consider the fact that people with Cancer have low levels of Glutathione, because of this, important exogenous antioxidants like Vitamin C and Vitamin E cannot do their job adequately to protect our body against disease.

    Endogenous Antioxidant Glutathione GSH
    Glutathione GSH plays a very important role in DNA repair. Healthy DNA is essential to prevent mutated cells from replicating itself which will lead to Cancer.

    It is a proven fact that if you have cancer, you have low levels of Glutathione GSH. However as of now, there's no documented scientific evidence that raising Glutathione levels can make us overcome Cancer if you already have one, research and clinical trials are still ongoing. But we already have witnessed several miracles, of patients with terminal cancer that survived by taking large dose of glutathione accelerator/booster. Some are claiming it as Placebo only but the important thing is, they continue to live.

    What Science have proven is that when you have high levels of glutathione gsh, you will be protected from free radical damage, all other Antioxidants like Vitamin C and Vitamin E can do their job efficiently, your vital organs will function better and you will have better functioning immune system. Generally speaking, having high levels of Glutathione GSH means having a healthier body.
  • Medical research supports that Glutathione protects from viruses

    “Without glutathione your entire defense (immune) system would surrender to the first virus you encountered and cease to function.” - Dr. Robert Keller

    Having sufficient levels of Glutathione in your body can significantly strengthen your immune system, thereby maximizing your body’s natural ability to defend itself against illness and disease.

    How can Glutathione Boosts Your Immune Health?

    Strengthens your immune system
    Defends against illness and disease
    Reduce inflammation
    Fights infection, injury, fatigue, stress and environmental toxins
    Functions as a powerful antioxidant and antitoxin

    Those suffering from chronic illnesses such as cancer, auto-immune diseases, heart disease, Alzheimers’s disease, liver disease, arthritis and asthma – to name just a few, consistently show depleted levels of Glutathione in their bodies. Glutathione is the body’s primary antioxidant, and is found in elevated concentrations into our 20’s, at which time the levels begin to decrease as we continue to age.

    Recent Medical Research: Glutathione (GSH) demonstrates Anti-viral Activity

    Within an in vitro model of Herpes simplex virus (HSV-1) infection, addition of GSH was able to decrease the amount of virus produced by infected cells. This report also demonstrated an acute depletion of GSH within HSV-1 infected cells less than 1hr after infection. The addition of GSH to the culture media increased the level of GSH in infected cells to levels just lower than that measured in non-infected cells and decreased the amount of virus produced by the infected cells by greater than 90%.

    Follow this link to read the entire text of published abstract on this study: Evidence for antiviral activity of glutathione... [Antiviral Res. 1995] - PubMed - NCBI

    Antiviral Res. 1995 Jun;27(3):237-53.

    Evidence for antiviral activity of glutathione: in vitro inhibition of herpes simplex virus type 1 replication.

    Palamara AT, Perno CF, Ciriolo MR, Dini L, Balestra E, D'Agostini C, Di Francesco P, Favalli C, Rotilio G, Garaci E.

    Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Italy.

    Abstract
    The role of glutathione (GSH) in the in vitro infection and replication of human herpes simplex virus type 1 (HSV-1) was investigated. Intracellular endogenous GSH levels dramatically decreased in the first 24 h after virus adsorption, starting immediately after virus challenge. The addition of exogenous GSH was not only able to restore its intracellular levels almost up to those found in uninfected cells, but also to inhibit > 99% the replication of HSV-1. This inhibition was concentration-dependent, not related to toxic effects on host cells and also maintained if the exogenous GSH was added as late as 24 h after virus challenge, i.e. when virus infection was fully established. Electron microscopic examination of HSV-1-infected cells showed that GSH dramatically reduced the number of extracellular and intracytoplasmic virus particles, whereas some complete nucleocapsids were still detected within the nuclei of GSH-treated cells. Consistent with this observation, immunoblot analysis showed that the expression of HSV-1-glycoprotein B, crucial for the release and the infectivity of virus particles, was significantly decreased. Data suggest that exogenous GSH inhibits the replication of HSV-1 by interfering with very late stages of the virus life cycle, without affecting cellular metabolism.
  • Antioxidants 101: Endogenous Vs Exogenous Antioxidant

    Free radicals - are highly reactive, unstable molecules that have lost one electron and are aggressively looking for a replacement. Free radicals are formed in the body, and its production is increased when we are exposed to such things as tobacco smoke, alcohol, insecticides, radiation and even to sunlight. Other causes are a high-fat diet, eating fried foods, or strenuous exercise. It is the free radical production from these sources that we need to be most concerned about. In a simple explanation, FREE RADICALS are responsible to cell damage.

    Exogenous Antioxidant - antioxidant that we obtain from our diet and supplements. Vitamin C and Vitamin E are the most popular exogenous antioxidant that floods the market.

    Endogenous Antioxidant - antioxidant produced by our body. More powerful free radical fighter than those you can get from your diet. The five important endogenous antioxidants are Superoxide Dismutase (SOD), Glutathione, Alpha Lipoic Acid (ALA), Catalase and Coenzyme Q10 (CoQ10).

    Our body produces more SOD, Catalase and Glutathione when certain free radicals are present. It is our body's Frontline defense (First Line of Defense).

    Important Roles of Endogenous Antioxidant:

    > SOD can convert the most reactive or most dangerous free radicals into hydrogen peroxide, which catalase and Glutathione can then turn into oxygen and water, neutralizing them.
    > ALA, Glutathione and CoQ10 has properties that can regenerate and recycle some exogenous antioxidants. **Example - Vitamin C (Ascorbate) donates an electron to a free radical to neutralize it, making it dehydroascorbate which has a half-life in the body of only a few minutes. If the dehydroascorbate is not rereduced (given back its lost electrons) back to ascorbate, it is irreversibly lost making it a weak free radical. Endogenous antioxidants can regenerate this dyhydroascorbate, turning it back to ascorbate form so it can combat another free radical again.

    What Makes Glutathione Stand Out from other Endogenous Antioxidant?
    Glutathione is present in each and every cell of our body, found in high concentrations in liver cells. It is the cell’s primary antioxidant against free radicals produced by toxic chemicals and viruses. Glutathione also plays an essential role in the liver’s detoxification process (Phase II system).
    Glutathione has the ability to repair DNA damage caused by free radicals at the cellular level, it plays a role in boosting the immune system and in slowing down the natural ageing process.... Glutathione indeed is the Most Important and Most Powerful Antioxidant inside our body.

    How Powerful is Glutathione?
    Antioxidant donates electron to free radicals to neutralize it. Let's make an example how many free radicals some popular antioxidants can neutralize:
    > Vitamin E - a molecule of vit.E has 3 electrons to share, meaning it can neutralize 3 free radicals at a time.
    > Vitamin C - has 2 to 5 electrons to share, means it can neutralize 2 to 5 free radicals at a time.
    > Glutathione - has 1 million electrons to share, it can neutralize 1million free radicals at a time as well as give back the lost electrons of exogenous antioxidants like vitamin c and vitamin e making them functional again.
    It is estimated that every one of the cells in our body receives 10,000 hits a day from free radicals, assuming we have 50 to 75 trillion cells, imagine the total hits from free radicals we encounter per day! If we will rely from exogenous antioxidants to neutralize that many free radicals, we would have to consume approximate amount of 375 oranges or 87 glasses of red wine or 120 vitamin C capsule! Glutathione being our body's frontline defense, do most of the work in neutralizing these free radicals.

    Important Facts:
    > Endogenous and Exogenous Antioxidants, revive and spare one another from destruction. So those exogenous antioxidants coming from our diet and supplements are also important.
    > Taking Vitamin C and Vitamin E and other exogenous antioxidant supplement is also needed if we need to give our body a boost by helping and aiding glutathione.
    > It is evident that we need to rely on replenishing glutathione at the cellular level to be healthier and live longer.
    > When we are Younger, our body is capable of producing enough endogenous antioxidants to combat free radicals on their own. Capability decreases as we age, making us vulnerable to sickness.

    For decades, the main problem encountered with glutathione sold as a supplement is that only very small amounts can be absorbed into the blood stream because of its large molecule size aside from our body breaks them down in the process of digestion.

    Scientific Breakthrough:
    Dr. Robert H. Keller has formulated a cost effective way to promote glutathione production at the cellular level.
  • bakit po d nagwowork well ang glutha with me. I took glutathion 14 years ago. It was just 250 mgs and i developed a big white patch (vitiligo) on my nose. And my inner lips lost its color So i stopped it. Four years ago, I was tempted to try it again, I tried the 2500mg. After three days, my vitiligo spread around my mouth.

    What do you think is wrong with my system?
  • beekai wrote: »
    bakit po d nagwowork well ang glutha with me. I took glutathion 14 years ago. It was just 250 mgs and i developed a big white patch (vitiligo) on my nose. And my inner lips lost its color So i stopped it. Four years ago, I was tempted to try it again, I tried the 2500mg. After three days, my vitiligo spread around my mouth.

    What do you think is wrong with my system?

    nothing wrong with your system. ready-made glutathione are useless if you want to optimize its function to fight illnesses. when taken orally, it is broken down as it passes the gi tract. with IV, it bypasses gi tract but it still can't get into the cells because whole glutathione molecule is too big to penetrate the cell's membrane. it will just stay in your bloodstream. that's when it suppresses the production of melanin in your skin giving a whitening effect.

    if you took it before to whiten your skin, it probably worked but it is too risky. some say you can be prone to skin cancer since there's less melanin or none at all to protect you from uv rays, and in your case, it only whitened a certain part of your body.. the best way to optimize your glutathione (gsh) is to take glutathione accelerator/enhancer/booster products. this is not intended to whiten your skin or as per gluta ads say 'will make you beatiful', 'glowing skin' and others.. but is designed to increase the natural production of glutathione from within the cells because it contains the raw materials needed (by the cells) to produce gsh. and when you have increased levels of gsh, you can prevent/fight diseases associated with low levels of glutathione (mentioned above).
  • Glutathione is Vital for the Eyes

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    The eyes contain very high concentrations of glutathione. Glutathione detoxifies the aqueous fluid of the inner eye and is essential for maintaining the transparency of the lens. Scientific studies show that glutathione plays an important role in the prevention of cataracts, glaucoma, retinal disease and diabetic blindness.

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  • Glutathione: The Great Protector

    If biochemistry were the stuff of comic books, antioxidants would be the superheroes — with glutathione (gloota-thigh-own) being no less than a cross between Superman and Underdog. As the most powerful antioxidant in the body, glutathione works around the clock to fend off nefarious characters. And yet, few people recognize its importance.

    Glutathione is likely to get more attention in the near future, as experts begin to connect the dots between depleted stores of the antioxidant and the likelihood of chronic disease. “If you haven’t heard of glutathione yet, you will,” says Mark Hyman, MD, founder of The UltraWellness Center in Lenox, Mass., and a pioneer in the field of functional medicine. “In terms of staying healthy, it is one of the most important molecules in the body."

    Glutathione is a triple threat to toxins. It neutralizes free radicals, enhances the immune system and detoxifies the liver. But some worry that it has met its match. The trappings of modern life — everything from refined foods to over-the-counter painkillers to stress — rob the body of this vital antioxidant. And, even if you’re doing everything right, aging takes a bite. Around age 45, our glutathione levels start to slip. Ultimately, those levels can dip as much as 50 percent below optimal as we age.

    Some scientists are now wondering if low glutathione levels aren’t partly to blame for the free-radical-induced illnesses so common in middle age and later, such as Alzheimer’s, cancer and heart disease. Indeed, research published in the New England Journal of Medicine found that, among people with heart disease, those with the least amount of glutathione in their blood were 30 percent more likely to have a heart attack than those with the most glutathione.

    Hyman didn’t understand the full ramifications of a glutathione deficiency until his own health was in peril. In the mid-1990s, he was besieged by muscle pain, brain fog and “bone-numbing” exhaustion. “I went from feeling really healthy one day to really sick the next,” he says.

    After months of medical sleuthing, he discovered he had mercury poisoning — probably due to eating contaminated fish and breathing tainted air while working in China. He suspects that the burden of detoxifying the mercury depleted his glutathione levels, leading his body to break down under the strain. “As you detoxify, your body uses up more and more of your glutathione stores until it’s gone,” he says. “That’s when you end up with toxic overload.”

    In exploring what went wrong, Hyman discovered he lacked a gene, called GSTM1, crucial to making and recycling glutathione. He estimates that roughly half of Americans are missing one or more of the genes necessary to produce enough of the antioxidant. The percentage climbs even higher among his critically ill patients, the vast majority of whom have rock-bottom glutathione levels. “At first I thought it was just a coincidence,” he says, “but I’ve come to realize that making and keeping a high level of glutathione is critical to preventing disease.”

    Gloota-what?
    Found in every cell in the body, glutathione protects the cell’s engine, called the mitochondria, from bacteria and viruses as well as toxins. It’s considered “the mother of all antioxidants,” as Hyman calls it, because all other antioxidants, including vitamin C and vitamin E, rely on it to give them a second life.

    The average antioxidant has a short life span, sacrificing itself whenever it wipes out a free radical. But glutathione carries enough extra zip to not only bring spent antioxidants back from the dead but also to recharge itself, explains Leslie Fuller, ND, an educator at the National College of Natural Medicine and practitioner at the Nature Cures Clinic, both in Portland, Ore.

    Most glutathione is made inside the body from three amino acids: glutamic acid, cysteine and glycine. In addition, some foods, particularly asparagus, spinach, avocado and squash, are high in a plant version of glutathione that the body converts to replenish its supply.

    Under healthy conditions, and in a healthy environment, our bodies would be able to churn out plenty of glutathione to meet our daily needs. But cigarettes, alcohol, caffeine, processed foods and certain medications deplete the body’s stash. So does stress. And as Hyman discovered, toxic surroundings may pose an even bigger threat to our body’s glutathione supply.

    Radical Riff-Raff
    To fully appreciate glutathione, it helps to know a little more about its nemesis: free radicals. Free radicals are unstable oxygen molecules created by our metabolism. The instability stems from a missing electron. In a mad attempt to find balance, the misfit molecules rip electrons from their neighbors. As a result, those molecules also turn into free radicals. This damage can eventually snowball and disrupt a cell’s integrity, causing it to behave abnormally.

    “Almost every chronic illness known to humankind has been linked in some measure to free-radical-induced tissue damage,” says Lise Alschuler, ND, FABNO, coauthor of The Definitive Guide to Cancer: An Integrative Approach to Prevention, Treatment, and Healing, Third Edition (Celestial Arts, 2010).

    That’s not to say the goal is zero emissions. Indeed, some free-radical damage is natural. Every breath inhaled, every calorie burned, every muscle contracted leaves a wisp of free radicals in its wake. “Even if we lived in a pristine environment, our bodies would make free radicals,” says Alschuler. And, as she explains, some free-radical damage is a good thing because a damaged cell is triggered to be either repaired or destroyed. By sparking either a renovation or a demolition, free-radical damage gets the body’s attention, and, if the body is healthy enough and the free-radical damage is not overly extensive, free radicals may play a role in preventing diseases like heart disease and cancer.

    Unfortunately, our bodies must contend with an ever-growing onslaught of free radicals in the environment. Free radicals hitchhike into the body on the backs of chemicals in the air, the water supply and the food chain. The cumulative load is called oxidative stress. Corrosion caused by oxidative stress (or oxidation) inside the body is often compared to the slow rusting of metal when it’s exposed to the elements.

    Protecting cells from oxidation is where antioxidants, particularly glutathione, come into play. All antioxidants retard oxidative stress, but because glutathione recharges its allies, it plays a particularly important role in helping the body keep up with our accelerated modern-day demands.

    “We are in a situation where our manufacturing and our recycling of glutathione is maxed out,” says David Perlmutter, MD, FACN, ABIHM, author of Power Up Your Brain: The Neuroscience of Enlightenment (Hay House, 2011). “We just can’t detoxify fast enough.”

    Cleanup Crew
    Found throughout the body, glutathione is concentrated in the liver. The body’s primary detox organ, the liver is charged with giving nutrients the nod to be absorbed and giving toxins the boot. But expelling a toxin isn’t easy. In phase one, liver enzymes must convert the toxin into a compound that can be flushed. In phase two, glutathione is used to grab hold of the toxin and escort it out of the body via urine or bile. If there isn’t enough glutathione on hand, the toxins stack up like so many cars in a traffic jam.

    Glutathione owes much of its detoxifying prowess to cysteine. A sulfur-rich amino acid, cysteine is abundant in eggs, garlic and whey protein. “Sulfur is a sticky, smelly molecule that acts like flypaper trapping toxins in the body,” explains Hyman. This is why vegetables high in sulfur, including garlic and onions, have been at the heart of detoxification diets for years.

    Another plant substance, called cyanohydroxybutene (found in broccoli, cauliflower and cabbage) helps restock the body’s glutathione supply. “We’ve always been taught that broccoli and other cruciferous veggies are important to the detox protocol, but we didn’t fully understand why,” says Perlmutter. “Now we know that it’s because they enhance glutathione production.”

    Green tea, fish oil and resveratrol also house substances that switch on genes responsible for making glutathione, Perlmutter notes. Aerobic exercise and yoga are thought to goose glutathione levels as well.

    Although glutathione doesn’t come in a simple pill form, Perlmutter says, “You can take and do things that turn on your body’s genes to make more glutathione, and that’s pretty powerful stuff. You are modifying your own genetic expression.”

    Logically, if more glutathione means better detoxification, people with the highest levels of the stuff should live the longest. That was the theory that drove Danish researchers to enroll 41 centenarians in a study of glutathione levels. Their results, published in the journal Age and Ageing, found that glutathione levels were highest in the healthiest seniors. Additionally, they discovered that the centenarians had higher levels of glutathione than people 20 to 40 years younger, hinting that glutathione may be one reason why their subjects had lived to such a ripe age.

    Need More? Make More
    Recognizing when the body is running low on glutathione takes some detective work. Because it oxidizes quickly outside the body, the antioxidant does not lend itself to a blood test. So some healthcare practitioners, like Hyman, look for missing genes. Others consult indirect biochemical markers, such as short telomeres (the caps of DNA on either end of a chromosome, like handles on a jump rope) or high levels of oxidation in the blood. A history of chronic illness is also a clue.

    But don’t wait until you’re sick to think about glutathione. High stress levels, certain medications, past infections and a poor diet can all nibble away at the body’s glutathione stash. The average American consumes only 35 milligrams of glutathione per day, says Alschuler, far short of the optimal daily intake of 250 milligrams. “This, coupled with decreasing glutathione production as we age, leaves most of us deficient.”

    The good news: Protecting your glutathione levels is fairly simple, says Perlmutter, and “the health implications can be profound.”

    Easy Ways to Maximize Glutathione Production and Activity
    Eat lots of glutathione-rich foods, such as asparagus, spinach, avocado, squash, melons, grapefruit and peaches. Whenever possible, eat these foods raw or minimally heated, since heat — and microwaving — tends to destroy antioxidants.

    Eat more colorful, antioxidant-packed produce, such as strawberries, bell peppers and mangoes, all of which are particularly high in vitamin C. The more one-shot antioxidants you’ve got on board, the less your body needs to lean on its glutathione reserves.

    Eat more foods high in cysteine. The sulfur-rich amino acid is a key building block for glutathione. The best sources are eggs, garlic and whey protein. If you buy whey protein, make sure it is bioactive and made from undenatured (or nondenatured) proteins, meaning the bond between the amino acids is preserved, and the cysteine is more bioavailable.

    Limit exposure to toxins by buying organic produce, filtering your water, cutting down on refined foods, and avoiding chemical-packed personal-care and cleaning products. Minimizing your toxic burden will help preserve your body’s ability to produce glutathione, and also reduce excess demands on your body’s glutathione supplies.

    Brain Buffer
    The brain makes up only 2 percent of the body’s weight but eats up roughly 20 percent of its oxygen. Because the body spews free radicals when it uses oxygen, the brain is awash in rogue molecules. Glutathione helps protect the brain against their ravaging effects.

    Uncontrolled free-radical damage is the tie that binds a handful of diseases that target the brain, including schizophrenia and Alzheimer’s. Evidence suggests that a shortage of glutathione is a factor in all of the above, but some of the most telling evidence is in people with Parkinson’s disease.

    Parkinson’s disease corrupts the files in the brain that make dopamine, a chemical instrumental in coordinating the body’s movements. When researchers looked at the brains of people with Parkinson’s disease, they discovered that the area that makes dopamine, the substantia nigra, contained up to 40 percent less glutathione than the rest of the organ. “So, here’s an area that’s being damaged by free radicals, that’s low in glutathione, and therefore [is] at more risk for free-radical damage,” says neurologist David Perlmutter, MD, FACN, ABIHM.

    While much about Parkinson’s disease remains a mystery, a role for glutathione seems certain. For his part, Perlmutter sees glutathione as a vital treatment option. “We are all about getting as much glutathione to the brain as possible,” he says. “It really is one of the most protective agents around.”

    Free-Radical Fighter
    Some free-radical damage is the natural byproduct of our body’s cellular processes; however, our bodies are made ever more vulnerable to an increasing amount of free-radical damage due to environmental factors, including the sun, pollution, poor nutrition and chronic stress.

    Enter glutathione, “the mother of all antioxidants,” which helps to recharge other antioxidants, thus protecting our cells from free-radical-induced oxidation.

    Toxin-Clearing Escort
    Glutathione is concentrated in the liver, the body’s primary detox organ. Glutathione grabs hold of toxins in the liver and escorts them out along with the body’s waste products.

    Too little glutathione? Toxins accumulate in the body and can contribute to many inflammation-based diseases.


    The Next-Best Things: Glutathione Precursors

    One reason that glutathione wallows in relative obscurity is that, unlike vitamin C or E, it isn’t easily shoehorned into a supplement you can swallow. “With glutathione it’s not that easy,” says David Perlmutter, MD, FACN, ABIHM, author of Power Up Your Brain: The Neuroscience of Enlightenment (Hay House, 2011).

    That’s because to succeed as an oral supplement, a nutrient must be able to wiggle through the intestinal wall and into the bloodstream, he explains. Otherwise it’s doomed to be destroyed in the gut. Here is where glutathione’s size works against it. A large molecule, called a tripeptide, glutathione cannot sneak through the intestinal wall intact. Instead, its three amino acids are broken apart during digestion and reassembled in the blood. (To get around this problem, many practitioners give therapeutic doses of glutathione intravenously.)

    Experts disagree on exactly how much oral glutathione reaches its final destination, but all agree the best bet is to deliver plenty of building blocks (a.k.a. precursors) the body needs to make glutathione on its own.

    In addition to eating glutathione-rich foods (see above) here are four more ways to get the raw materials you need:

    N-acetyl-cysteine (NAC): NAC supplements are made synthetically from the amino acid l-cysteine. The small molecule slips seamlessly into the blood where it combines with glutamic acid and glycine to restock the liver’s supply of glutathione. A potent liver detoxifier, NAC is approved by the Food and Drug Administration as a tool to limit liver damage caused by acetaminophen overdose.

    Alpha-lipoic acid (ALA): A key antioxidant, alpha-lipoic acid (not to be confused with alpha-linolenic acid) is both water- and fat-soluble, meaning it can vanquish free radicals throughout the body, including in the brain. That’s no small matter, since oxidative damage is tied to many brain diseases, including Parkinson’s and Alzheimer’s. The best dietary sources of ALA are organ meats (such as liver) and brewer’s yeast.

    Selenium: A mineral found in Brazil nuts, meat and seafood, selenium boosts the body’s ability to recycle glutathione. “Eating just one to two Brazil nuts daily supplies enough selenium for most people,” says Lise Alschuler, ND, FABNO, coauthor of The Definitive Guide to Cancer: An Integrative Approach to Prevention, Treatment, and Healing, Third Edition (Celestial Arts, 2010).

    Vitamin C: One of the most well-known antioxidants, vitamin C is glutathione’s crime-fighting cohort. In studies, people with high levels of vitamin C typically have high glutathione levels, as well. The two antioxidants work in tandem to rid the body of water-soluble toxins.
  • As per PubMed:

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    To date:

    Vitamin C

    Vitamin E

    Glutathione

    Oxidative Stress and Vitamin C = 5260 results

    Oxidative Stress and Glutathione = 24947 results


    Glutathione, being the master scavenger in the body, works wonders when delivered correctly.
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