Claudine is not only reigning in television shows, but in movies as well. At a young age, she already starred with veteran actors Dolphy and Aga Muhlach, and actresses such as the "Star for All Seasons" Vilma Santos, "Diamond Star" Maricel Soriano , and "Megastar" Sharon Cuneta .
Claudine was Seiko's bet for stardom. Her first three films under Seiko were Kumusta Ka, Aking Mahal?, Taong Gubat and Pulis Patola. She was paired with the dashing and debonair newcomer Emil Benedicto. She also did Kung Sakali Man and God...Save the Babies under this film outfit.
Though an exclusive Seiko contract star before, Claudine was still allowed to accept two assignments with Star Cinema, Home Along Da Riles (The Movie) and May Minamahal.
Claudine starred in more than thirty movies and she is now an exclusive contract star of Star Cinema. She has a number of memorable movies such as Dahil Mahal na Mahal Kita, Anak, Got 2 Believe, Kailangan Kita, Milan, Nasaan Ka Man and Sukob.
In Dahil Mahal na Mahal Kita, Claudine played the role of Mela, with a reputation of a bad girl in the campus and is going steady with Mr. Bad Boy. She then meets Mr. Perfect who does not care about her. Challenged, she pursued Mr. Perfect who eventually learned to love her despite her reputation. Claudine was very convincing in this role, a true versatile actress.
In the 2000 movie Anak, Claudine played a very challenging role as Carla, a daughter who ran loose and wild for lack of guidance. Claudine received a lot or praises from this movie and people started naming her as the next Vilma Santos.
In Got 2 Believe, Claudine played the role of Toni, a wedding coordinator who believes in true love and is in search of finding Mr. Right. In this movie, Claudine showed that she couldnít only play dramatic roles but comedic roles as well.
In Kailangan Kita, Claudine was Lena, a daughter who forgoes her personal happiness to keep her family from falling apart. Claudine had a grand slam nomination for best actress for this movie.
In Milan, Claudine played the role of Jenny, an imposing figure in the Filipino community of migrant workers, whose dreams of grandeur have clouded her need for personal relationships. Claudine won her first best actress award from this movie, beating the likes of Ms. Maricel Soriano, Ms. Nora Aunor and Judy Ann Santos. Also, this movie was invited to the 2005 Cannes International Film Festival. Claudine attended the red carpet screening and was overjoyed by the appreciation shown by the people all over the world.
In Nasaan Ka Man, we can see a very different Claudine. Pilar was difficult to portray because according to Claudine it was something new. She never played a role like it before and was at first, scared on whether she can act the role right or not. Well, she portrayed the role magnificently because Claudine received three best actress awards from this movie.
And in Sukob, Claudine played the role of Diana, who, together with her sister Sandy is in search of the answer to the uncanny and terrible events that happened in their lives. This movie is the highest grossing film in the Philippines; it reached the 200 million mark.
2010 - The remarkable comeback of the Box Office Queen tested once again in her new movie In Your Eyes a certified blockbuster hit with co-star Anne Curtis and Richard Gutierrez
Ciara (Claudine Barretto) is a senior physical therapist who works for a rehabilitation center in the United States. She has devoted her entire life to her younger sister Julia (Anne Curtis) who was left in her care after the untimely demise of their parents.
Other movies include Sige, Ihataw Mo, Eat All You Can, Lagalag: The Eddie Fernandez Story, May Minamahal, Muntik na Kitang Minahal, Mangarap Ka, Pare Ko, Radio Romance, May Nagmamahal Sa Iyo, Oki Dok Doc (The Movie), Madrasta, Home Along da Riles 2, Calvento Files (The Movie), Flames the Movie, Soltera, Mula sa Puso (The Movie), Oopps, Teka Lang.. Diskarte Ko 'To!, and Dubai.