Columbia Pictures is currently in talks with Gary Ross (Pleasantville) to direct the upcoming Spider-Man spin-off feature Venom and rewrite the script.
Ross will reportedly start work on Venom as soon he's done with his rewrite of Spider-Man 4. Since the last we heard about the Venom script was that Zombieland's screenwriters Rhett Reese and Paul Wernick had submitted a draft to Marvel and Sony, it's safe to assume that Ross will be rewriting their work. Though after enjoying the insanity that was Zombieland, I can't imagine that Reese and Wernick's script would require a rewrite of any sort.
Venom should hit theaters in 2011, but it seems unlikely that Topher Grace, who brought the role to life in Spider-Man 3, will pick up the mask again.