In infectious diarrhea, the toxins are still inside the GI tract, unless one flushes it out completely by defecation. By taking Loperamide, one decreases the movement of the intestines, thereby reducing the incidence of bowel urgency, also keeping the toxins inside the GI tract for sometime until it is eventually excreted from the body. With this in mind, the toxins are still inside the body. Instead of flushing the toxins out of the system, the medicine will keep it there for quite sometime..