Know any great business establishment in a lousy location

[hep2b]

Location, Location, Location. No matter how great your product or service is, the business will suffer for being in the wrong place. Would you know any exceptions?

[Rambus]

Oil exploration and mining come to mind.

[lupuS]

Making/storing prohibited substances, prostitution, and gambling might also fit the bill, although I definitely DO NOT ENDORSE these activities.

[KuyaDanny]

If you are able to get good telecomms access, a call center, customer support, or back office can work in a "poor location". These types of business do not mainly rely on physical access to customers in order to be successful. Besides, a poor location often means cheap rent - further reducing overhead and improving the business's chances for profitability.